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Kinetics parameters for interactions of β-lactam antibiotics with PBP2
| β-Lactam | k2 (s–1 × 103) | ks (μM) | k2/ks (M–1s–1) | k3 (s–1 × 106) | Reference |
|---|---|---|---|---|---|
| WYBQ-4 | 4.872 ± 0.14 | 28 ± 1.24 | 174 ± 8.45 | 11±1.32 | |
| Ceftaroline | 20 ± 4 | 4,500 ± 640 | — | 47 | |
| Nitrocefin | 3.7 ± 0.3 | 192 ± 24 | 19.0 ± 3.0 | 7.2 ± 0.1 | 48 |
| Cefepime | 1.5 ± 0.1 | 1,618 ± 145 | 0.9 ± 0.1 | 5.9 ± 0.5 | 48 |
| Ceftazidime | 1.0 ± 0.1 | 671 ± 116 | 1.5 ± 0.3 | 3.2 ± 0.2 | 48 |
| Ampicillin | 3.4 ± 0.1 | 668 ± 124 | 5.0 ± 1.0 | 3.2 ± 0.1 | 48 |
