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Cytotoxicity and inhibitory effects of the screened anticoagulant drugs (ticagrelor, fondaparinux sodium, dabigatran, and heparin) against SARS-CoV-2 reveal their safety indexes.
| Compound | Cytotoxicity Concentration (CC50) µM | Inhibitory Concentration (IC50) µM |
Safety Index (SI) |
|---|---|---|---|
| Ticagrelor | 141.90 | 5.60 | 25.33 |
| Fondaparinux sodium | 151.50 | 8.60 | 17.60 |
| Dabigatran | 141.80 | 9.40 | 15.10 |
| Heparin | 262.00 | 105.90 | 2.47 |
