. 2022 Sep 8;10(5):e01415-22. doi: 10.1128/spectrum.01415-22

TABLE 2.

Summary of the comparative analysis of 40 putative proteins of FPV (see Table S1 for full details)

Genetic variation (amino acid mutation and/or insertion and/or deletion)	Gene	FPV ORF
Geographically distinct between Korean strain versus US strain	α-SNAP	11
	V-type Ig domain	17
	Ankyrin repeat gene family protein	18^a, 115, 216, 223, 230, 242–243
	G protein-coupled receptor gene	27^b
	Transforming growth factor-β	80^a
	DNA polymerase	94^c
	N1R/p28 gene family	124^b
	Late transcription factor VLTF-4	142
	Molluscum contagious virus MC089L	145^b
	Immunodominant virion protein	168^b
	C-type lectin gene	239^b
Common to four attenuated strains (V-CMP, V-DS, V-KR and FP9)	G protein-coupled receptor gene	27^b
	Phosphopantothenate-cysteine	71
	DNA polymerase	94^c
	Variola B22R	97
	N1R/p28 gene family	124^b
	Molluscum contagious virus MC089L	145^b
	Immunodominant virion protein	168^b
	Early transcription factor, VETF-L	171
	A type inclusion protein	190, 191
	Ankyrin repeat gene family protein	219
	C-type lectin gene	239^b
Unique in the diphtheritic type strains	Ankyrin repeat gene family protein	18^a, 26
	Transforming growth factor-β	80^a
	DNA polymerase	94^c
	Variola B22R	98, 122

ORF18 and 80 have genetic variations showing in the geographically distinct of FPVs and in only diphtheritic type strains.

ORF 27, 124, 145, 168, and 239 have genetic differences showing in the geographically distinct and common to the attenuated strains.

ORF 94 has genetic difference relating geographically distinct, showing in only diphtheritic type strains and common to the attenuated strains.