Figure 1.

The structural components, types, and physiological role of mTOR signaling pathway. Upward and downward direction of arrows indicate the increase or decrease of process or substance. When growth factor stimulates TRK receptor then it triggers the downregulation of Ras, Raf Mek, Erk, IRS, P13k, PIR3, and Akt which ultimately cause inhibition of TSC1/TSC2 complex which ultimately inhibits lysosome biogenesis autophagy and upregulates the process of ribosome/mitochondria biogenesis and lipid/protein/nucleotide synthesis and energy metabolism by inhibiting Rheb. On the other hand, Rag A/B and Rag C/D cause the same effect by amino acids upregulation.