Table 2.
mTOR inhibiting drugs for IBD.
| Drugs | Mode of Action | References |
|---|---|---|
| Mesalamine | Inhibition of mTORC1 signaling pathway | [160] |
| Tacrolimus, | Inhibition mTORC1 signaling pathway | [161,162,163] |
| Everolimus | Inhibition mTORC1 signaling pathway | [162,163] |
| Sirolimus | Inhibition mTORC1 signaling pathway | [142,163] |
| Methotrexate | Promotes OXPHOS (Oxidative phosphorylation) by activating AMPK and blocking mTORC1 | [142] |
| Corticosteroids | Inhibits glycolysis by blocking mTORC1 | [142] |
| Aminosalicylates | Inhibits glycolysis by blocking mTORC1 | [142] |
| Tacrolimus | Inhibits glycolysis by blocking mTORC1 | [142] |