TABLE 4.
Frequency of major and minor nucleotide substitutions for a specific mutation
| Position of mutation in the genome | Genomic region | Nucleotide before mutation (reference) | Nucleotide(s) after mutation |
Amino acid(s) in: |
|||
|---|---|---|---|---|---|---|---|
| Wild-type protein (reference) | Mutant protein |
||||||
| Major | Minor | Major | Minor | ||||
| 241 | 5′ UTR | C241 | 241T | 241A | |||
| 1059 | nsp2 (ORF1ab) | C1059 | 1059T | T265 | 265I | ||
| 3037 | nsp3 (ORF1ab) | C3037 | 3037T | F106 | 106F | ||
| 14408 | nsp12 (ORF1ab) | C14408 | 14408T | 14408A | P323 | 323L | 323H |
| 23403 | Spike | A23403 | 23403G | D614 | 614G | ||
| 25563 | ORF3a | G25563 | 25563T | 25563A/25563C | Q57 | 57H | 57Q/57H |
| 28881 | Nucleocapsid | G28881 | 28881A | 28881T | R203 | 203K | 203M |
| 28882 | Nucleocapsid | G28882 | 28882A | 28882T | R203 | 203R | 203S |
| 28883 | Nucleocapsid | G28883 | 28883C | 28883A | G204 | 204R | 204R |