Table 1.

Summarized effect of ERAP, HLA-C, KIR polymorphisms on susceptibility to infertility and recurrent implantation failure.

ERAP, HLA-C, KIR Combination	Associated Combination	Compared Groups	p	pcorr.	OR	95% CI	Effect	Table
Female ERAP/male HLA-C
ERAP1 rs30187 C>T/HLA-C	TT/C1C2	IVF vs. Fertile	0.006	0.050	2.843	1.30–6.92	↑	Supplementary Table S2
ERAP1 rs27044 C>G/HLA-C	CC/C1C1	RIF vs. SIVF	0.005	0.044	0.343	0.15–0.75	↓	Supplementary Table S2
ERAP1 rs27044 C>G/HLA-C	CC/C1C2	SIVF vs. Fertile	0.003	0.027	0.442	0.25–0.78	↓	Supplementary Table S2
Female ERAP/male HLA-C/female KIR
ERAP1 rs27044 C>G/HLA-C/KIR	CC/C1C2/Bx	RIF vs. Fertile	0.004	0.037	0.428	0.23–0.78	↓	Supplementary Table S3
ERAP1 rs27044 C>G/HLA-C/KIR	CG/C1C2/Bx	RIF vs. Fertile	0.006	0.050	2.313	1.25–4.33	↑	Supplementary Table S3
Male ERAP/female HLA-C/female KIR
ERAP1 rs30187 C>T/HLA-C/KIR	CT/C2C2/AA	RIF vs. SIVF	0.005	0.049	24.000	1.76–1549.16	↑	Supplementary Table S4
Male ERAP/male HLA-C/female KIR
ERAP1 rs27044 C>G/HLA-C/KIR	GG/C1+/AA	RIF vs. SIVF	0.005	0.031	0.114	0.01–0.66	↓	Supplementary Table S5
ERAP1 rs27044 C>G/HLA-C/KIR	CG/C2C2/Bx	RIF vs. SIVF	0.004	0.033	0.096	0.01–0.56	↓	Supplementary Table S5

↑—susceptibility; ↓—protection; IVF-ET—in vitro fertilization embryo transfer; RIF—recurrent implantation failure; SIVF—successful pregnancy after IVF-ET; p—probability; p_corr.—probability after Bonferroni correction; OR—odds ratio; 95% CI—confidence interval from two-sided Fisher’s exact test.