Table 1.

Tissue engineering ovary models in vivo.

Reference	Scaffold	Host	Follicles	Sterilization	Graft Location	Endocrine Function	IVF	Spontaneous Pregnancy	Results
Gosden 1990 [42]	plasma clot	mouse	mouse	x-ray or ovariectomy	ovarian bursa	yes	n/a	yes	normal follicular development
Telfer et al. 1990 [52]	collagen	mouse	mouse	ovariectomy	kidney capsule	yes	yes	n/a	normal follicular development
Carroll, Gosden 1993 [45]	plasma clot	mouse	mouse	ovariectomy	ovarian bursa	yes	n/a	yes	normal follicular development
Dolmans et al. 2008 [46]	plasma clot	mouse	human	n/a	ovarian bursa	n/a	n/a	n/a	antral follicle development
Vanacker et al. 2012 [55]	alginate/ matrigel	mouse	mouse	ovariectomy	peritoneum	n/a	n/a	n/a	graft–host integration
Vanacker et al. 2014 [54]	alginate	mouse	mouse	ovariectomy	peritoneum	n/a	n/a	n/a	antral follicle development
Smith et al. 2014 [47]	fibrin	mouse	mouse	ovariectomy	ovarian bursa	yes	n/a	n/a	antral follicle development
Rajabzadeh et al. 2015 [48]	fibrin	mouse	mouse	ovariectomy	subcutaneous neck	n/a	n/a	n/a	antral follicle development
Kniazeva et al. 2015 [49]	fibrin fibrin/collagen fibrin/alginate	mouse	mouse	ovariectomy	ovarian bursa	yes	n/a	yes	sustainable ovary graft
Paulini et al. 2016 [51]	fibrin fibrin/ HA	mouse	human	n/a	peritoneum	n/a	n/a	n/a	secondary follicle development
Kim et al. 2016 [56]	PEG-VS	mouse	mouse	ovariectomy	ovarian bursa	yes	n/a	n/a	antral follicle development
Laronda et al. 2017 [53]	3D printed gelatin	mouse	mouse	ovariectomy	ovarian bursa	yes	n/a	yes	antral follicle development