FIG 2.

Fold changes of MICs to antibiotics of P. aeruginosa clinical isolate populations evolved under 9 days sub-MIC selective windows of ciprofloxacin. The heatmap represents the fold changes between the MICs of the 9-day evolved populations and their corresponding parental strains. The populations included are the ones which resistance level to ciprofloxacin was ≥2-fold of the parental strain MIC value (as determined using MIC test strips that allow to discriminate small differences in MICs). Said populations of each strain are vertically ordered from the lowest to the highest sub-MIC within their windows. MIC values are encompassed in Table S1 (CIP) and Table S2 (the rest of the drugs). CIP, ciprofloxacin, LEV, levofloxacin; CAZ, ceftazidime; AMK, amikacin; ATM, aztreonam; IPM, imipenem; FOF, fosfomycin.