Table 2. Task-related BOLD activations between PTLD and control participants.
Regions are based on Talairach coordinates27 and listed anterior-posterior (y-plane).
| Cluster size | T-value | x, y, z (MNI) | Brain region | GM/WM | p-value |
|---|---|---|---|---|---|
| Controls > PTLD | |||||
| 17 | 3.14 | 58, 14, 26 | Right inferior frontal gyrus (BA 9) | GM | < .005 |
| 10 | 3.01 | 40, 12, 30 | Right inferior frontal gyrus (BA 9) | GM | < .005 |
| 124 | 3.69 | 48, 0, 44 | Right precentral gyrus (BA 6) | WM (64%) | < .001 |
| 95 | 3.68 | 8, -24, 8 | Right thalamus | GM | < .001 |
| 21 | 3.08 | 44, -36, 44 | Right inferior parietal lobule (BA 40) | GM | < .005 |
| PTLD > Controls | |||||
| 120 | 3.37 | 0, 50, 24 | Left medial frontal gyrus (BA 9) | GM | < .005 |
| 33 | 3.22 | -18, 48, 26 | Left superior frontal gyrus (BA 9) | WM (89%) | < .005 |
| 40 | 3.82 | -22, 38, 36 | Left middle frontal gyrus (BA 8) | WM (41%) | < .001 |
| 56 | 3.97 | -18, 24, 40 | Left middle frontal gyrus (BA 8) | WM (80%) | < .001 |
| 46 | 3.72 | -34, 18, 38 | Left precentral gyrus (BA 9) | WM (99%) | < .001 |
| 26 | 3.31 | -56, -4, 6 | Left precentral gyrus (BA 6) | GM | < .005 |
| 45 | 3.61 | 62, -10, 8 | Right superior temporal gyrus (BA 42)* | GM | < .001 |
| 18 | 3.15 | 2, -14, -4 | Right thalamus | GM | < .005 |
| 23 | 3.33 | -62, -16, 6 | Left superior temporal gyrus (BA 41)* | GM | < .005 |
A = Brodmann Area; GM = gray matter; WM = white matter.
* = positive BOLD signal indicates greatest activity in the control participants during the control condition, which reversed the BOLD signal interpretation in this double subtraction method. The percentage of WM computed within a cluster is noted in parentheses in the GM/WM column (reporting those with WM > 50%). Cluster information is reported at p < .005, uncorrected.