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Antioxidant effect of esculetin: Esculetin blocks the activity of H2O2 which further inhibits the MMP-1 and lipid peroxidation in cell membranes. Esculetin prevents the brain from amyloid-induced oxidative stress via activating the Nrf2 and increasing the levels of glutathione, thus inhibiting oxidative stress. ↑: Overexpression; ↓: low expression; ⊣: inhibition.
