Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Hepatoprotective effects of esculetin: Esculetin downregulates the expression of SREBP1c, fatty acid synthetase, and TGF-β-mediated hepatic fibrosis. Esculetin also activates AMPK signaling pathway and inhibits the action of PPARγ, Fasn, Pap, and Dgat2, thus inhibiting the pathogenesis of the fatty liver disease. ↑: Overexpression; ⊣: inhibition.
