Figure 2.

AhR signaling in pesticide-induced dysbiosis, and inflammation. AhR acts as a ligand-activated sensor of endogenous and exogenous factors. After dimerization with AhR nuclear translocator (ARNT), it binds to response elements in the DNA and promotes the transcription of genes involved in physiological pathways, notably CYP1A expression, contributing to maintain the epithelial barrier integrity. However, in dysbiosis, deregulated production of microbiome metabolites is responsible for altered stimulation of the AhR pathway, promoting inflammation. Created with BioRender.com.