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. 2022 Oct 14;23(20):12317. doi: 10.3390/ijms232012317

Figure 1.

Figure 1

Sequence alignment of aquaporins from different species. Multiple sequence alignment by Clustal Omega The alignment of different water-selective aquaporins from plants (Fragaria ananassa, Spinacia oleracea and Arabidopsis thaliana) and animals (Rattus norvegicus, and Homo sapiens) shows highly conserved residues that are critical for the selective conduction mechanism of water molecules. The transmembrane segments are highlighted in green, the NPA motifs in red, the Ar/R selectivity filter in yellow (His and Arg residues) and the H-bond donor residues of the cytosolic aperture in blue. Alignment symbols: (.) Aminoacid with weakly similar properties. (:) Aminoacid with strong similar properties. (*) Single conserved aminoacid residue.