Table 2.

In vivo studies focused on the collagen family.

Collagen Type	Cancer Type	Effect	References
COL1	Pancreatic Cancer	COL1 deletion in myofibroblast pancreatic tumor promotes progression and immunosuppression; CXCR2 and CCR2 inhibition reverses COL1-deletion-induced tumor progression	[113]
	Breast cancer	Promotes mammary tumor initiation and progression; COX2 may be an effective therapeutic target	[100,114,115]
COL7	Lung cancer	Promotes tumor growth and poor prognosis	[113]
COL10A1	Colorectal cancer	Promotes tumor growth and metastasis via epithelial–mesenchymal transition (EMT)	[108]
COL11A1	Breast cancer	Promotes tumor growth and metastasis	[116]
COL12	Breast cancer orthotropic mice model	Promotes metastatic dissemination by decreasing collagen I bundle thickness and tumor stiffness	[44]
COL18A1	Breast cancer	Promotes cancer growth and metastasis by interacting with EGFR/ErbB and activating MAPK/ERK1/2 and PI3K/Akt pathways	[117]