Table 1.
Regulation of NEDD4-like E3 ligases in various cancers in clinical studies.
| Cancer Type | Tissues | Results | Reference |
|---|---|---|---|
| Breast Cancer | BC tissues | ↑WWP1 a | [150] |
| BC tissues | ↑NEDD4, P34SEI-1 | [151] | |
| BC tissues | ↑WWP1 | [152] | |
| BC tissues | ↑NEDD4 | [54] | |
| Colorectal Cancer | CRC tissues | ↑NEDD4 | [153] |
| CRC tissues | ↑NEDD4 ↓NEDD4L |
[76] | |
| CRC tissues | ↑NEDD4 | [109] | |
| Endometrial Cancer | EC tissues | ↓NEDD4L | [154] |
| EC tissues | ↑NEDD4, FoxM1 | [155] | |
| Gall bladder Cancer | Gallbladder cancer tissues | ↑NEDD4L, MMP-1, MMP-13 | [156] |
| Gastric Cancer | Gastric cancer tissues | ↑NEDD4 | [153] |
| Gastric cancer tissues | ↓NEDD4L | [157] | |
| Gastric cancer tissues | ↑NEDD4 | [126] | |
| Gastric cancer tissues | ↓NEDD4L ↑HIF-1α | [158] | |
| Glioma/Glioblastoma | Glioma tissues | ↓NEDD4L | [159] |
| Glioma tissues | ↑NEDD4 ↓CNrasGEF | [160] | |
| Glioma tissues | ↑NEDD4 | [161] | |
| Glioma tissues | ↑SMURF1 | [162] | |
| Liver Cancer | HCC tissues | ↑NEDD4, p-Akt ↓PTEN | [111] |
| HCC tissues | ↓NEDD4L | [163] | |
| Lung Adenocarcinoma | NSCLC tissues | ↑NEDD4 ↓PTEN | [97] |
| Lung adenocarcinoma tissues | ↑NEDD4, p-Akt ↓PTEN |
[121] | |
| NSCLC tissues | ↓NEDD4L | [164] | |
| Melanoma | Melanoma tissues | ↑NEDD4L | [165] |
| Ovarian Cancer | Ovarian cancer tissues | ↓NEDD4L | [166] |
| Prostate Cancer | PC tissues | ↓NEDD4L | [167] |
| PC tissues | ↑NEDD4L, PSMB5, PSMC4 | [168] |
↑—Increase/upregulation; ↓—decrease/downregulation, a—Differential expression from Category I to IV.