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. 2022 Oct 15;23(20):12369. doi: 10.3390/ijms232012369

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of ¹⁷⁷Lu-DOTATATE and EBRT on ROS induction in melanoma (HBL and MM162), multiple myeloma (COLO-677 and EJM) and GEP (MIA-PACA-2 and HT-29) cell lines. ROS were assessed immediately (within 15 min) after 4 h incubation with 5 MBq of ¹⁷⁷Lu-DOTATATE (purple) or 2 Gy EBRT (pink) and at day 3. Results are normalized against the non-treated counterpart (black dotted line) (n = 6 from 3 independent experiments). NS: not statistically significant; * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001. The following symbols were used for the comparison between ¹⁷⁷Lu-DOTATATE and EBRT results: # p ≤ 0.05; ## p < 0.01; ### p < 0.001.