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Effect of 177Lu-DOTATATE and EBRT on DNA damage repair in melanoma (HBL and MM162), multiple myeloma (COLO-677 and EJM) and GEP (MIA-PACA-2 and HT-29) cell lines. Total DNA damage (pATM+ γH2AX-, pATM- γH2AX+, pATM+ γH2AX+) was assessed at different timepoints after 4 h incubation with 5 MBq of 177Lu-DOTATATE (purple) or 2 Gy EBRT (pink). Results are represented as mean ± SEM (n = 3 from 3 independent experiments for 15 min, 3.5 h and 10-day time points).
