Table 1.
The coefficient of drug interaction (CDI) and amplification factor (AF) for 177Lu-DOTATATE and EBRT combined with olaparib at minimal toxic concentration. CDI = survival%(A + B)/(survival%(A) × survival%(B)), where A is either 177Lu-DOTATATE or EBRT and B is olaparib. CDI < 1 indicates synergism, CDI = 1 additivity and CD > 1 antagonism. AF (%) = (survival%(A)-survival%(A + B))/survival%(A) × 100, where A is either 177Lu-DOTATATE or EBRT and B is olaparib. NA = not applicable.
| CDI | AF (%) | |||
|---|---|---|---|---|
| 177Lu-DOTATATE | EBRT | 177Lu-DOTATATE | EBRT | |
| HBL | 0.84 | 0.72 | 20 | 34 |
| MM162 | 0.95 | 0.80 | 12 | 26 |
| COLO-677 | NA | NA | 0 | 5 |
| EJM | NA | NA | 7 | 5 |
| MIA-PACA-2 | NA | 0.58 | 0 | 43 |
| HT-29 | NA | 0.63 | 4 | 34 |