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. 2022 Oct 20;23(20):12630. doi: 10.3390/ijms232012630

Figure 2.

Figure 2

Effects of MStim on VTA GABA neuron firing rate after reinstatement ethanol during withdrawal. (A–C) Representative traces for GABA neuron response for (A) EtOH alone, (B) EtOH + MStim and (C) saline + MStim. (D) Baseline firing rate differences between the three groups. Note that EtOH alone maintained a higher baseline firing rate. (E) MStim blocks chronic EtOH-induced desensitization of GABA neurons to EtOH reinstatement. (F) Time course data with 50 s bins demonstrating disparate effects among groups. Asterisks (**, ***) indicate significance levels p < 0.01 and 0.001, respectively.