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. 2022 Oct 18;23(20):12444. doi: 10.3390/ijms232012444

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ASPHmod-pulsed moDCs induce fewer T_reg cells. (A) Representative flow cytometric analysis of a single individual. (B) Number of CD4⁺FoxP3⁺ T cells after restimulation with no antigen-, ASPH- or ASPHmod-pulsed DCs. Data represent the mean ± SD of a single individual donor assessed in triplicate: ** significantly different, p < 0.01, *** significantly different, p < 0.005 (one-way ANOVA). (C) Fold change in CD4⁺FoxP3⁺ T cells relative to cells restimulated with the non-pulsed moDC control. Data represent the means ± SD of five individuals: ** significantly less, p < 0.01 (Mann–Whitney test). (D) Relative T cell response of nine individuals to ASPH- versus ASPHmod-pulsed moDCs.