Figure 2.

Schematic representation of VTN functions in different cells of the nervous system. The differentiation of embryonic stem cells can be promoted by changing ECM and selecting VTN. Furthermore, VTN acts on cerebellar granule cells by 2 ways: inducing CREB phosphorylation to regulate differentiation and utilizing RGD site to extend neurites, and it is also closely related to glial cells. VTN can promote microglia migration and inhibit phagocytosis. Moreover, it can induce neurogenesis and neuroprotection of astrocytes and proliferation of dendritic cells. Created with BioRender.com (accessed on 11 October 2022).