Table 1.

Overview of VTN in neurodegenerative diseases.

Diseases	Roles of VTN in Neurodegenerative Diseases	References
Age-related macular degeneration	a major component of drusen; involved in the pathogenesis of AMD	[65,66]
Alzheimer’s disease	exists in plaques and neurofibrillary tangles; inhibits the aggregation of β-peptide; regulates β-amyloid precursor protein; misfolding of VTN tends to amyloidosis	[18,70,72,73]
Multiple sclerosis	increased expression in active MS; regulates oligodendrocyte proliferation, survival and development	[75,76,77,78]
Stroke	inhibits post-stroke neurogenesis; aggravates neurological dysfunction	[80,81]