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. 2022 Oct 18;23(20):12472. doi: 10.3390/ijms232012472

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Multivariate analysis of 2−group lipoprotein and metadata comparison plotted via PCA scores plot (Panel (a), outliers shown), via the oPLS−DA regression model analysis scores plot (Panel (b)). Additionally, the top 25 data entries were plotted according to their variable importance (VIP) score based on the oPLS−DA regression model analysis ranked by T score (Panel (c)). Finally, a comparison of the top 25 Spearman correlations was performed in the context of CSF h−tau biomarker levels and visualized via a PatternSearch plot for a group of patients (n = 17) who showed the most apparent changes in the T score (Panel (d)).