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A three-enzyme cascade for the synthesis of modified nucleosides. RK—ribokinase (ec:2.7.1.15), PPM—phosphopentomutase (ec: 5.4.2.7), NP—nucleoside phosphorylase, usually purine nucleoside phosphorylase (ec:2.4.2.1). Base—nucleobase substrate/nucleoside moiety.
