Table 4.
Genetic codon mutation characteristics.
| Gene/Amino Acids | Study(n) | Events/ Mutations(n) |
ES% | 95% CI | I2 (%) | Heterogeneity Chi-Squared | p |
|---|---|---|---|---|---|---|---|
| RpoB (codon: 439–459) | |||||||
| Ser (Serine) | 10 | 58/73 | 54.17 | 53.02~69.40 | 79.10 | 43.06 | 0.000 |
| Thr (Threonine) | 3 | 5/24 | 19.54 | 3.88~35.20 | 0.00 | 0.62 | 0.733 |
| Asp (Aspartic) | 8 | 13/92 | 12.32 | 5.67~18.98 | 0.00 | 0.64 | 0.913 |
| Gln (Glutamine) | 6 | 12/51 | 19.29 | 8.88~29.71 | 0.00 | 4.14 | 0.529 |
| Ala (Alanine) | 3 | 6/21 | 24.52 | 6.98~42.06 | 5.20 | 2.11 | 0.348 |
| Leu (Leucine) | 3 | 3/25 | 7.47 | −2.80~17.74 | 0.00 | 0.16 | 0.688 |
| His (Histidine) | 2 | 4/37 | 10.52 | 0.76~20.27 | 0.00 | 0.00 | 0.949 |
| Val (Valine) | 4 | 4/36 | 10.10 | 0.33~19.86 | 0.00 | 0.55 | 0.909 |
| Gly (Glycine) | 4 | 7/28 | 25.40 | 3.01~47.78 | 53.30 | 6.42 | 0.093 |
| Phe (Phenylalanine) | 2 | 2/18 | 10.13 | −3.72~23.98 | 0.00 | 0.24 | 0.628 |
| Folp1 (codon: 44–64) | |||||||
| Pro (Proline) | 10 | 87/112 | 83.97 | 77.58~90.37 | 37.80 | 14.47 | 0.107 |
| Thr (Threonine) | 11 | 44/133 | 31.36 | 5.32~57.41 | 95.60 | 229.51 | 0.000 |
| Arg (Arginine) | 2 | 2/37 | 5.31 | −1.91~12.54 | 0.00 | 0.04 | 0.845 |
| GyrA (codon: 81–101) | |||||||
| Ala (Alanine) | 5 | 31/68 | 75.18 | 68.54~88.62 | 63.60 | 11.00 | 0.027 |
| Gly (Glycine) | 3 | 7/24 | 26.00 | 10.14~41.88 | 40.80 | 3.38 | 0.185 |
| Ser (Serine) | 2 | 7/20 | 23.64 | 7.779~39.493 | 86.80 | 7.58 | 0.006 |
ES = drug-resistance rate, 95% CI = confidence interval.