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Proposed mechanisms of FLT3 inhibitor resistance and the established overcoming agents. Schematic of FLT3 inhibitor resistance mechanism including several types of FLT3 mutations were present. Several targeted agents such as venetoclax, proteasome inhibitors, multikinase inhibitors, novel dual agents, and novel FLT3 inhibits biologic agents, could overcome and thus lead to cancer cell growth, proliferation, and prolonged survival of the FLT3 mutations by several mechanisms.
