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. 2022 Oct 20;23(20):12582. doi: 10.3390/ijms232012582

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Possible association of the 46/1 haplotype and MPNs. (1) Medullary stromal cells positive for 46/1 may show dysregulation in genes, such as INSL4 and INSL6, which may be involved in the (2) excessive production of proinflammatory and promyeloid mediators. These cytokines (3) interact with normal and haplotype-positive and JAK2V617F multipotent stem cells, promoting (4) exacerbated proliferation (proliferative advantage) of the mutated cells, which, in turn, continue their process of (5) differentiation and cell maturation, and trigger the (6) clonal myeloproliferative disorder.