Table 1.

Available CL-PDT systems.

Type	Chemiluminescent Substrate	PS	Cell	IC50 μM	Animal	Disease	Ref.
Covalent CL-PDT	luminol derivative	erythrosine	–	–	–	–	[30]
	luminol	chlorin e6	RAW264.7 B16F10 MOVAS MCF-7 A549	498.8 414.2 267.9 153.0 123.7	male BALB/c mice C57BL/6 mice BALB/c nude mice	ulcerative colitis tumor	[31]
	luminol	chlorin e6	4T1 HCT116 A549	53.8 67.3 124.0	Male BALB/c mice	tumor	[32]
	luminol derivative	BODIPY	Hep-2	–	–	–	[33]
	Schaap’s adamantylidene-dioxetane	erythrosin B	MCF7 MDA-MB231	14.0 1.9	–	–	[34]
Noncovalent CL-PDT	luminol	hematoporphyrin	Friend’s Leukemia K-562 U-7.6	0.08 0.3 0.5	–	–	[35]
	luminol	5-aminolevulinic acid	Caco-2	–	–	–	[36]
	luminol	meta-tetra(hydroxyphenyl)- chlorin	MCF-7, C6, NIH 3T3	–	–	–	[37]
	luminol	poly [2-methoxy-5-(2- ethylhexyloxy)-1,4-phenylenevinylene]	Hela	–	–	–	[38]
	luminol	Fe(III) Deuteroporphyrin IX	HeLa, MCF-7, H1299 cells, RAW264.7	–	nude mice	tumor	[39]
	TCPO	chlorin e6	HT29 cells	–	male BALB/c nude mice	tumor	[40]
	CPPO	DPAC-S	293T, KYSE-150	–	–	–	[41]
	CPPO	tetraphenylporphyrin	HeLa	–	BALB/c nude mice	tumor	[42]
	CPPO	TBD	4T1	–	BALB/c mice	tumor	[43]
	HPOX	protoporphyrin	SW620	–	–	–	[44]
	Peroxalate ester oligomer	mesotetraphenylporphine	LoVo	–	–	–	[45]

TCPO: bis [3,4,6-trichloro2-(pentyloxycarbonyl)phenyl]oxalate; CPPO: bis [2,4,5-trichloro-6-(pentyloxycarbonyl)phenyl] oxalate; DPAC-S: 4,4’-(dibenzo[a,c]phenazine-9,14-diyl) pyridin-1-ium bromide; TBD: TPE-BT-DC; HPOX: hydroxybenzyl alcohol-incorporating copolyoxalate.