Table 2.

Guidelines for the use of SGLT-2is.

Year	Guidelines	SGLT-2is	Indications
2019	American College of Cardiology (ACC)/American Heart Association (AHA) [33]	Canagliflozin, dapagliflozin, and empagliflozin	T2D and ASCVD
2019	European Society of Cardiology (ESC) [34]	Canagliflozin, dapagliflozin, and empagliflozin	T2D and CVD
2020	Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease [35]	Canagliflozin, dapagliflozin, and empagliflozin	T2D and CKD
2021	ESC/Heart Failure Association (HFA) of the ESC [37]	Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin	T2D and CVD
		Dapagliflozin, empagliflozin, and sotagliflozin	T2D and HFrEF
2021	ACC Expert Consensus Decision Pathway for Optimization of Heart Failure Treatment [36]	Dapagliflozin and a empagliflozin a	HFrEF with or without T2D
2022	American Diabetes Association [31,32]	SGLT-2i drug class recommended An SGLT-2i with proven benefit for the individual patient’s comorbidities is recommended (CVD: canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin; DKD: canagliflozin, dapagliflozin, and empagliflozin)	T2D, ASCVD, HF, and DKD

^a Prescribed in conjunction with a background of guideline-directed medical therapy for HF. ASCVD, atherosclerotic cardiovascular disease; CKD, chronic kidney disease; CVD, cardiovascular disease; DKD, diabetic kidney disease; HF, heart failure; HFrEF, HF with reduced ejection fraction; SGLT-2i, sodium-glucose cotransporter-2 inhibitor; T2D, type 2 diabetes.