Figure 5.

Regulatory action in cis and chromatin conformation control alternative transcription. Condition 1: There is no transcription from TSS1. Acetylated histones (orange circle) at the gene body downstream TSS1 are associated with a relaxed chromatin state. The transcription factor Y, which activates transcription at the TSS2, can bind. Condition 2: Transcription from TSS1 leads to histone deacetylation. This reduction in histone acetylation leads to a more condensed chromatin conformation that occludes the binding of transcription factor Y, thereby repressing transcription from TSS2.