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ACE2 converts AngII to Ang1-7. Ang1-7 then binds to MAS, causes an elevation of NO and prostacyclin and thus has anti-inflammatory, antioxidant and anti-thrombotic effects. When SARS-CoV-2 binds to the ACE2 receptor, this pathway is downregulated. Abbreviations used: MAS: a transmembrane G-protein coupled receptor; AngII: angiotensin II; Ang1-7: angiotensins 1-7; NO: nitric oxide.
