Table 3.
Comparisons of optical coherence tomography parameters in patients with diabetic macular edema according to the response to intravitreal dexamethasone treatment.
| Characteristics | Better Responder DME (n = 22) |
Lesser Responder DME (n = 9) |
p-Value |
|---|---|---|---|
| CMT (µm) Before injection After injection △CMT (µm) |
577.68 ± 138.95 287.32 ± 80.20 290.36 ± 123.31 |
463.22 ± 61.27 365.22 ± 66.27 98.00 ± 40.37 |
0.004 a 0.016 a <0.001 a |
| DRIL | |||
| Absent Present |
2 (9.1) 20 (90.9) |
0 (0) 9 (100.0) |
1.000 b |
| Intraretinal cysts in the INL | |||
| Absent Present |
1 (4.5) 21 (95.5) |
1 (11.1) 8 (88.9) |
0.503 b |
| Intraretinal cysts in the ONL | |||
| Absent Mild Moderate Severe |
0 (0) 0 (0) 2 (9.1) 20 (90.9) |
0 (0) 1 (11.1) 1 (11.1) 7 (77.8) |
0.273 b |
| Intraretinal cysts in the ONL | |||
| Optical density Optical density ratio |
38.54 ± 15.24 1.55 ± 0.88 |
60.22 ± 21.88 3.46 ± 1.26 |
0.020 a <0.001 a |
| ELM integrity | |||
| Normal Partly disrupted Moderately disrupted Severely disrupted |
5 (22.7) 11 (50.0) 4 (18.2) 2 (9.1) |
3 (33.3) 4 (44.4) 0 (0) 2 (22.2) |
0.422 b |
| EZ integrity | |||
| Normal Partly disrupted Moderately disrupted Severely disrupted |
5 (22.7) 9 (40.9) 4 (18.2) 4 (18.2) |
3 (33.3) 4 (44.4) 0 (0) 2 (22.2) |
0.575 b |
| SRF | |||
| Absent Present |
13 (59.1) 9 (40.9) |
5 (55.6) 4 (44.4) |
1.000 b |
| HRF | |||
| Absent <10 ≥10 |
0 (0) 10 (45.5) 12 (54.5) |
0 (0) 4 (44.4) 5 (55.6) |
1.000 b |
Values are presented as the mean ± standard deviation or number (percent). CMT = central macular thickness; DME = diabetic macular edema; DRIL = disorganization of the retinal inner layers; ELM = external limiting membrane; EZ = ellipsoid zone; HRF = hyperreflective foci; INL = inner nuclear layer; ONL = outer nuclear layer; SRF = subretinal fluid. a Mann–Whitney U test; b Fisher’s exact test.