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. 2022 Oct 26;17(10):e0274546. doi: 10.1371/journal.pone.0274546

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© 2022 Zhou et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A) mRNA expression of topoisomerase family genes in the GTEx normal tissues. (B) Differential mRNA expression of topoisomerase family genes in paired tumor and paraneoplastic tissues. The bubble was filtered by the fold change (FC>2) and significance (FDR ≤0.05). (C) Differential expression of topoisomerase family genes associated with cancer subtypes. The black outline border of bubble indicates FDR≤0.05. (D) The trend of the gene expression of topoisomerase family genes from stage I to stage IV in different cancers. The blue trend line and red trend line represent fall and rise tendency, respectively. (E) Survival analysis of topoisomerase family genes in different types of cancer.