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. 2022 Oct 26;17(10):e0274546. doi: 10.1371/journal.pone.0274546

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© 2022 Zhou et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) Differential methylation status of topoisomerase family genes in paraneoplastic and tumor tissues in different cancer types. The bubble size is positively correlated with the FDR significance, and the bubble was filtered by FDR significance (FDR ≤0.05). (B) Relationship between methylation level and mRNA expression. (C) Analysis of methylation survival of topoisomerase family genes in different cancers. (D) Survival curves between hypermethylation and hypomethylation groups of TOP1MT in KIRC and HNSC.