Table 1.
Inhibitory effects of twenty-four compounds on the pathogenic Sporothrix species.
| Compounds | Minimum Inhibitory Concentration (µm) a | ||
|---|---|---|---|
| S. brasiliensis | S. globosa | S. schenckii | |
| Reference antifungal | |||
| Itraconazole | 0.125 | 0.03 | 0.25 |
| Antifungals | |||
| Commercial drugs | |||
| Abafungin | 0.5 | 0.5 | 1 |
| Amorolfine | 0.125 | 0.5 | 1 |
| Butenafine | 0.25 | 1 | 0.25 |
| Ciclopirox | 0.5 | 0.03 | 1 |
| Deferasirox | 0.5 | 0.5 | >1 |
| Eberconazole | 0.125 | 0.03 | 0.5 |
| Isavuconazonium | 0.5 | 0.03 | 0.5 |
| Ketoconazole | 0.25 | 0.125 | 0.125 |
| Luliconazole | 0.004 | 0.004 | 0.004 |
| Miconazole | 0.125 | 0.03 | 0.125 |
| Ravuconazole | 1 | 0.03 | 0.125 |
| Terbinafine | 0.5 | 0.5 | 0.125 |
| New drugs b | |||
| Olorofim | 0.06 | 0.03 | 0.06 |
| New molecules | |||
| MMV1634360 | 1 | >1 | 0.25 |
| MMV1634491 | 1 | 0.03 | >1 |
| Antibacterials | |||
| Commercial drugs | |||
| Alexidine | 1 | 0.5 | 0.25 |
| New molecules | |||
| MMV1579784 | 0.5 | >1 | >1 |
| MMV1579786 | 0.25 | 0.03 | >1 |
| MMV1579788 | 0.5 | >1 | >1 |
| MMV1782140 | 0.25 | >1 | 1 |
| Antivirals | |||
| New drugs b | |||
| Rubitecan | 0.25 | >1 | 1 |
| New molecules | |||
| MMV019724 | 0.25 | >1 | 1 |
| MMV642550 | 0.25 | >1 | >1 |
a Minimum inhibitory concentration was defined as the concentration that inhibited at least 50% of fungal growth. b Drugs in clinical trials.