Table A1.
GRADE Summary of evidence of the results according to their certainly and their importance using the GRADE tool.
| Assessment Cernainly | No. de Pacientes | Effect | Certainly | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Studies | Study Design | Risk of Bias | Inconsistency | Indirectly Evidence | Imprecision | Otrhers | [Intervention Group ] | [Comparation Group] | Relative(95% CI) | Absolute(95% CI) | ||
| Pain intensity short-term | ||||||||||||
| 7 | RCTs | Serious a | Serious b | Not serious | Serious d | None | 131 | 115 | - | SMD 0.75 less (1.27 less to 0.23 less) | ⨁◯◯◯Very Low | Critical |
| Function short term | ||||||||||||
| 6 | RCTs | Serious a | Serious b | Not serious | Serious d | None | 100 | 30 | - | SMD 0.96 less (1.58 less to 0.34 less) | ⨁◯◯◯Very Low | Critical |
| Pain intensity medium term | ||||||||||||
| 2 | RCTs | Serious a | Serious c | Not serious | Serious e | None | 39 | 38 | - | SMD 0.49 less (1.45 less to 0.46 higher) | ⨁◯◯◯Very Low | Critical |
| Pain intensity long term | ||||||||||||
| 2 | RCTs | Serious a | Serious c | Not serious | Serious e | None | 39 | 38 | - | SMD 0.24 less (0.68 less to 0.2 higher) | ⨁◯◯◯Very Low | Critical |
| Function medium term | ||||||||||||
| 2 | RCTs | Serious a | Serious c | Not serious | Serious e | None | 39 | 38 | - | SMD 0.14 less (0.58 less to 0.3 higher) | ⨁◯◯◯Very Low | Critical |
| Function long term | ||||||||||||
| 2 | RCTs | Serious a | Serious c | Not serious | Serious e | None | 39 | 38 | - | SMD 0.05 less (0.5 less to 0.39 higher) | ⨁◯◯◯Very Low | Critical |
CI: Confidence interval; SMD: Standarized mean difference; RCTs: Randomized controlled trials. EXPLANATIONS: a. More than 25% of the participants were from studies with poor or fair methodological quality, considering this aspects: Lack of allocation concealment, random allocation and/or sample size calculation, participant and personnel blinding, blinding of outcome assessors. b. Significant heterogeneity of the studies or if the I2 value was greater than 50%. c. Significant heterogeneity of the studies (different interventions in the control and intervention groups). d. The 95% CI of the SMD was <0.2 points. e. Fewer than 100 participants were included. High: We are very confident that the true effect is close to the estimate of the effect. Moderate: We are moderately confidence in the effect estimate. The true effect is close to the estimate of the effect, but the result can be different. Low: Confidence in the effect estimate is limited, the true effect can be substantially different from the estimate of the effect. Very Low: There is little confidence in the effect estimate, the true effect is likely to be substantially different from the estimate effect.