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Effects of emicizumab on the clot waveform analysis (CWA)-activated partial thromboplastin time (APTT). Upper, NP (normal plasma); FVIIID, FVIII-deficient plasma; number mg/mL, emicizumab concentration; navy-blue, fibrin formation curve; pink curve, 1st derivative curve; light-blue curve, 2nd derivative curve. All assays were performed more than three times to confirm the reproducibility.
