Table 1.
The heights of the fibrin formation curve in the clot wave analysis of thrombin time.
| FVIII-Deficient Plasma | Normal Plasma | |||
|---|---|---|---|---|
| Thrombin Concentration | With Emicizumab | Without Emicizumab | With Emicizumab | Without Emicizumab |
| (a) (mm Absorbance) | (b) (mm Absorbance) | (c) (mm Absorbance) | (d) (mm Absorbance) | |
| 1.0 IU/mL | 993 ± 31 ***### | 957 ± 49 ***### | 1043 ± 38 | 1047 ± 45 |
| 0.5 IU/mL | 893 ± 21 ***### | 776 ± 71 ***### | 1097 ± 25 | 1203 ± 35 |
| 0.1 IU/mL | 812 ± 39 ***### | 502 ± 35 ***### | 1156 ± 49 | 1203 ± 49 |
The heights of fibrin formation at 400 s are shown. ***, p < 0.001 in comparison to (c); ###, p < 0.001 in comparison to (d); there were no significant differences between (a) and (b) or between (c) and (d). All assays were performed more than three times to confirm the reproducibility.