Table 1.
Selectivity and cytotoxicity of the NB in prostate cancer cells. IC50s were determined after 48 h of treatment using MTT assay. The values are represented as mean ± SD. Selectivity index (SI) was calculated as follows: [mean IC50 in noncancer cells]/[mean IC50 in cancer cells]. Docetaxel was used as a reference drug.
| Compound | IC50 [µM] | Mean IC50, Cancer Cells | Mean IC50, Noncancer Cells | Selectivity Index (SI) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Prostate Cancer Cells | Noncancer Cells | ||||||||||||
| PC3 | PC3-DR | DU145 | 22Rv1 | VCaP | LNCaP | PNT2 | RWPE-1 | HEK293 | MRC-9 | ||||
| NB [µM] | 6.03 ± 1.18 | 3.63 ± 1.03 | 12.97 ± 2.69 | 3.02 ± 2.5 | 0.143 ± 0.145 | 12.15 ± 2.97 | 25.13 ± 5.92 | 16.4 ± 1.87 | 9.3 ± 1.57 | 11.12 ± 4.3 | 6.46 | 15.49 | 2.4 |
| Doce-taxel [nM] | 7.49 ± 7.09 | 324.9 ± 21.7 | 2.2 ± 0.6 | 0.6 ± 0.12 | 0.23 ± 0.22 | 5.06 ± 0.58 | >500 | 0.42 ± 0.23 | 11.49 ± 3.22 | >500 | 56.75 | 252.98 | 4.5 |