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. 2022 Oct 4;12(10):1646. doi: 10.3390/jpm12101646

Table 4.

Nitration, carbonylation, thiol-disulphide homeostasis, and methylated arginine in studied groups.

Parameters Melanoma
(52 Subjects)
Control
(35 Subjects)
p Value
Nitration
Nitrotyrosine (umol/L) 0.38 ± 0.04 0.13 ± 0.02 ˂0.001
Carbonylation
PCO (μmol/L) 37.82 ± 5.14 22.51 ± 2.21 ˂0.001
4-HNE (μgl/mL) 21.15 ± 7.62 14.05 ± 1.39 ˂0.001
TBARS (μmol/L) 3.24 ± 0.41 1.97 ± 0.13 ˂0.001
MDA (ng/mL) 36.07 ± 5.40 20.08 ± 1.32 ˂0.001
Thiol-disulphide homeostasis
NT (μmol/L) 355.92 ± 8.53 401.83 ± 4.89 ˂0.001
TT (μmol/L) 407.23 ± 7.40 440.89 ± 4.78 ˂0.001
DS (μmol/L) 25.65 ± 1.62 19.50 ± 0.53 ˂0.001
DS/NT 7.21 ± 0.55 4.85 ± 0.15 ˂0.001
DS/TT 6.30 ± 0.42 3.98 ±1.27 ˂0.001
NT/TT 87.39 ± 0.85 91.15 ± 0.25 ˂0.001
Methylated arginine
SDMA (μmol/L) 0.96 ± 0.10 0.50 ± 0.03 ˂0.001
ADMA (μmol/L) 0.86 ± 0.09 0.58 ± 0.05 ˂0.001
ADMA/SDMA 0.90 ± 0.07 1.10 ± 0.10 ˂0.001

PCO = carbonylated proteins; 4-HNE = 4-hydroxy-2-nonenal; MDA = malondialdehyde; TBARS = thiobarbituric acid-reactive substances; NT = native thiol; TT = total thiol; DS = disulfide; SDMA = symmetric dimethylarginine; ADMA = asymmetric dimethylarginine.