Table 4.
Parameters |
Melanoma (52 Subjects) |
Control (35 Subjects) |
p Value |
---|---|---|---|
Nitration | |||
Nitrotyrosine (umol/L) | 0.38 ± 0.04 | 0.13 ± 0.02 | ˂0.001 |
Carbonylation | |||
PCO (μmol/L) | 37.82 ± 5.14 | 22.51 ± 2.21 | ˂0.001 |
4-HNE (μgl/mL) | 21.15 ± 7.62 | 14.05 ± 1.39 | ˂0.001 |
TBARS (μmol/L) | 3.24 ± 0.41 | 1.97 ± 0.13 | ˂0.001 |
MDA (ng/mL) | 36.07 ± 5.40 | 20.08 ± 1.32 | ˂0.001 |
Thiol-disulphide homeostasis | |||
NT (μmol/L) | 355.92 ± 8.53 | 401.83 ± 4.89 | ˂0.001 |
TT (μmol/L) | 407.23 ± 7.40 | 440.89 ± 4.78 | ˂0.001 |
DS (μmol/L) | 25.65 ± 1.62 | 19.50 ± 0.53 | ˂0.001 |
DS/NT | 7.21 ± 0.55 | 4.85 ± 0.15 | ˂0.001 |
DS/TT | 6.30 ± 0.42 | 3.98 ±1.27 | ˂0.001 |
NT/TT | 87.39 ± 0.85 | 91.15 ± 0.25 | ˂0.001 |
Methylated arginine | |||
SDMA (μmol/L) | 0.96 ± 0.10 | 0.50 ± 0.03 | ˂0.001 |
ADMA (μmol/L) | 0.86 ± 0.09 | 0.58 ± 0.05 | ˂0.001 |
ADMA/SDMA | 0.90 ± 0.07 | 1.10 ± 0.10 | ˂0.001 |
PCO = carbonylated proteins; 4-HNE = 4-hydroxy-2-nonenal; MDA = malondialdehyde; TBARS = thiobarbituric acid-reactive substances; NT = native thiol; TT = total thiol; DS = disulfide; SDMA = symmetric dimethylarginine; ADMA = asymmetric dimethylarginine.