Table 6.
HIF-1a and HIF-2a levels in melanoma according to Clark level.
| Parameters | Clark Level | ||||||
|---|---|---|---|---|---|---|---|
| II | III | IV | V | ||||
| HIF-1a (ng/mL) | 61.34 ± 17.21 | 86.74 ± 26.83 | p1 < 0.05 | 99.66 ± 37.98 |
p1 < 0.05 p2 < 0.05 |
111.62 ± 46.03 |
p1 < 0.05 p2 < 0.05 p3 < 0.05 |
| HIF-2a (ng/mL) | 2.68 ± 0.28 | 3.22 ± 0.35 | p1 < 0.05 | 3.45 ± 0.42 |
p1 < 0.05 p2 ˃ 0.05 |
3.67 ± 0.59 |
p1 < 0.05 p2 < 0.05 p3 < 0.05 |
| HIF-1a/HIF-2a | 35.82 ± 8.86 | 28.12 ± 8.40 | p1 < 0.05 | 26.41 ± 8.02 |
p1 < 0.05 p2 > 0.05 |
18.9 ± 6.69 |
p1 < 0.05 p2 < 0.05 p3 < 0.05 |
HIF-1a = hypoxia-inducible factor=1a; HIF-2a = hypoxia-inducible factor-2a; p1 = Clark level (III, IV, and V vs. II); p2 = Clark level (IV and V vs. III); p3 = Clark level (V vs. IV).