Table 11.
Nitration and carbonylation in melanoma according to Breslow index.
| Parameters | Breslow Index | ||||||
|---|---|---|---|---|---|---|---|
| <1.0 | 1.01–2.0 | 2.01–3.0 | >3.01 | ||||
| Nitrotyrosine (umol/L) | 0.33 ± 0.03 | 0.36 ± 0.02 | p1 < 0.05 | 0.41 ± 0.02 |
p1 < 0.05 p2 > 0.05 |
0.40 ± 0.02 |
p1 < 0.05 p2 < 0.05 p3 > 0.05 |
| Carbonylation | |||||||
| PCO (μmol/L) | 34.28 ± 2.26 | 36.84 ± 5.86 | p1 < 0.05 | 40.85 ± 4.80 |
p1 < 0.05 p2 < 0.05 |
43.01 ± 2.73 |
p1 < 0.05 p2 < 0.05 p3 < 0.05 |
| 4-HNE (μgl/mL) | 18.44 ± 6.82 | 21.26 ± 7.92 | p1 < 0.05 | 21.84 ± 7.70 |
p1 < 0.05 p2 > 0.05 |
23.08 ± 8.05 |
p1 < 0.05 p2 < 0.05 p3 > 0.05 |
| TBARS (μmol/L) | 3.06 ± 0.36 | 3.27 ± 0.42 | p1 < 0.05 | 3.18 ± 0. 36 |
p1 < 0.05 p2 < 0.05 |
3.74 ± 0.08 |
p1 < 0.05 p2 < 0.05 p3 < 0.05 |
| MDA (ng/mL) | 31.92 ± 3.51 | 35.73 ± 6.19 | p1 < 0.05 | 38.85 ± 3.37 |
p1 < 0.05 p2 < 0.05 |
41.20 ±1.09 |
p1 < 0.05 p2 < 0.05 p3 < 0.05 |
PCO = carbonylated proteins; 4-HNE = 4-hydroxy-2-nonenal; MDA = malondialdehyde; TBARS = thiobarbituric acid-reactive substances; p1 = Breslow indexes 1.01–2.0, 2.01–3.0, and >3.01 vs. <1.0; p2 = Breslow indexes 2.01–3.0 and >3.01 vs. 1.01–2.0; p3 = Breslow index >3.01 vs. 2.01–3.0.