Table 13.
Nitration and carbonylation according to melanoma stage.
| Parameters | Melanoma Stage | ||||||
|---|---|---|---|---|---|---|---|
| I | II | III | IV | ||||
| Nitration | |||||||
| Nitrotyrosine (umol/L) | 0.35 ± 0.04 | 0.37 ± 0.03 | p1 > 0.05 | 0.39 ± 0.06 |
p1 < 0.05 p2 < 0.05 |
0.42 ± 0.05 |
p1 < 0.05 p2 < 0.05 p3 < 0.05 |
| Carbonylation | |||||||
| PCO (μmol/L) | 32.91 ± 3.45 | 35.84 ± 4.37 | p1 < 0.05 | 39.68 ± 5.08 |
p1 < 0.05 p2 < 0.05 |
42.86 ± 7.69 |
p1 < 0.05 p2 < 0.05 p3 < 0.05 |
| 4-HNE (μgl/mL) | 19.85 ± 6.89 | 20.67 ± 8.01 | p1 > 0.05 | 21.49 ± 7.94 |
p1 < 0.05 p2 > 0.05 |
22.62 ± 7.65 |
p1 < 0.05 p2 < 0.05 p3 > 0.05 |
| TBARS (μmol/L) | 3.06 ± 0.37 | 3.27 ± 0.42 | p1 < 0.05 | 3.15 ± 0.34 |
p1 < 0.05 p2 > 0.05 |
3.61 ± 0.32 |
p1 < 0.05 p2 < 0.05 p3 < 0.05 |
| MDA (ng/mL) | 31.46 ± 3.51 | 36.01 ± 6.5 | p1 < 0.05 | 38.06 ± 3.76 |
p1 < 0.05 p2 < 0.05 |
41.01 ± 1.09 |
p1 < 0.05 p2 < 0.05 p3 < 0.05 |
PCO = carbonylated proteins; 4-HNE = 4-hydroxy-2-nonenal; MDA = malondialdehyde, TBARS = thiobarbituric acid-reactive substances; p1 = melanoma stages II, III, and IV vs. I; p2 = melanoma stages III and IV vs. II; p3 = melanoma stage IV vs. III.