Table 18.

The interdependence between HIF-NO axis and damage-related molecular pattern in melanoma group.

Metabolites		HIF1a	HIF2a	HIF1a/HIF2a	Direct Nitrite	Nitrate
Direct nitrite	r	0.654	0.331	0.342	-	-
	p	0.018	0.036	0.004	-	-
Nitrate	r	0.730	0.470	0.375	-	-
	p	0.020	0.006	0.030	-	-
3-nitrotirosine	r	0.311	0.490	0.578	0.870	0.860
	p	0.028	0.041	0.001	0.001	0.002
Carbonylic groups	r	0.401	0.720	0.653	0.520	0.430
	p	0.018	0.006	0.001	0.001	0.001
4-HNE	r	0.392	0.822	0.720	0.510	0.470
	p	0.002	0.001	0.001	0.001	0.008
TBARS	r	0.412	0.630	0.750	0.376	0.609
	p	0.001	0.001	0.001	0.022	0.010
MDA	r	0.371	0.520	0.540	0.510	0.420
	p	0.002	0.010	0.002	0.002	0.040
NT	r	−0.530	−0.491	0.320	−0.510	−0.150
	p	0.001	0.004	0.020	0.001	0.260
TT	r	−0.553	−0.367	0.450	−0.422	−0.110
	p	0.002	0.038	0.020	0.003	0.650
DS	r	0.287	0.281	0.140	0.768	0.297
	p	0.043	0.002	0.420	0.040	0.030
DS/NT	r	−0.301	−0.250	0.090	0.130	0.310
	p	0.015	0.072	0.470	0.201	0.140
DS/TT	r	−0.404	−0.221	0.212	0.176	0.130
	p	0.041	0.059	0.320	0.177	0.111
NT/TT	r	0.398	0.306	0.169	0.160	−0.340
	p	0.051	0.040	0.350	0.432	0.020
SDMA	r	0.110	0.146	0.210	0.195	0.211
	p	0.010	0.176	0.210	0.360	0.342
ADMA	r	0.490	0.587	0.730	0.684	0.810
	p	0.031	0.028	0.002	0.001	0.001
ADMA/SDMA	r	−0.098	0.203	0.320	0.126	0.260
	p	0.520	0.043	0.033	0.218	0.430

HIF-1a = hypoxia-inducible factor-1a; HIF-2a = hypoxia-inducible factor-2a; PCO = carbonylated proteins; 4-HNE = 4-hydroxy-2-nonenal; MDA = malondialdehyde; TBARS = thiobarbituric acid-reactive substances; NT = native thiol; TT = total thiol; DS = disulfide; SDMA = symmetric dimethylarginine; ADMS = asymmetric dimethylarginine; r = correlation coefficient; p = statistical significance.