Table 3.

Nested case-control analysis for factors associated with ischemic heart disease in the primary dysmenorrheal cohort.

Variable	Ischemic Heart Disease
	Yes (n = 338)		No (n = 18,117)		Odds Ratio (95% Confidence Interval)
	n	%	n	%	Crude	p -Value	Adjusted	p -Value
Age group (years)
15–29	105	31.1	13,728	75.8	1.00		1.00
30–40	105	31.1	3212	17.7	4.27 (3.25–5.62)	<0.0001	3.95 (3.00–5.21)	<0.0001
40–50	128	37.8	1177	6.50	14.2 (1.09–18.5)	<0.0001	11.3 (8.55–15.0)	<0.0001
Baseline comorbidities (yes vs. no)
Diabetes	10	2.96	223	1.23	2.45 (1.29–4.65)	0.006	0.72 (0.36–1.46)	0.370
Hypertension	36	10.7	217	1.20	8.93 (6.79–14.2)	<0.0001	2.50 (1.64–3.81)	<0.0001
Hyperlipidemia	24	7.10	275	1.52	4.96 (3.22–7.64)	<0.0001	1.30 (0.79–2.15)	0.302
Arrhythmia	38	11.2	395	2.18	5.69 (4.00–8.08)	<0.0001	3.30 (2.25–4.86)	<0.0001
Thyroid disease	35	10.4	1033	5.70	1.91 (1.34–2.73)	0.0004	1.17 (0.80–1.71)	0.407
Migraine	23	6.80	666	3.68	1.91 (1.24–2.94)	0.003	1.26 (0.81–1.98)	0.308
Medicine use
NSAID	6	1.78	126	0.70	2.58 (1.13–5.90)	0.025	1.95 (0.81–4.71)	0.136
Hormones	1	0.30	15	0.08	3.59 (0.47–27.2)	0.216	NA