Table 3.
Baseline characteristics, laboratory results and clinical outcomes of COVID-19 patients from 2022 categorized by vaccination status. Data are n (%), and median (interquartile range, IQR), unless specified otherwise.
| 2020 | 2022 Unvaccinated (<2 Doses) | 2022 Vaccinated (≥2 Doses) | p-Value 2022 Unvaccinated vs. Vaccinated | p-Value 2020 vs. 2022 Unvaccinated | |
|---|---|---|---|---|---|
| n | 116 | 50 | 216 | ||
| Age (years) | 67.0 (50.0, 84.0) | 72.0 (56.0, 81.0) | 72.0 (57.5, 82.0) | 0.98 * | 0.66 |
| Male | 57 (49.1%) | 21 (42.0%) | 117 (54.2%) | 0.12 | 0.40 |
| Weight (kg) | 77.0 (62.0, 96.0) | 80.0 (63.0, 100.0) | 77.0 (67.0, 92.0) | 0.31 * | 0.39 |
| Fully vaccinated | 0 (0.0%) | 0 (0.0%) | 216 (100%) | <0.001 | 1.00 |
| Days from symptom onsent to admission | Not collected | 3.0 (1.0, 7.0) | 4.0 (2.0, 8.0) | 0.63 | N/A |
| Venous thrombosis | 2 (1.7%) | 0 (0.0%) | 4 (1.9%) | 0.33 | 0.35 |
| ICU | 18 (15.5%) | 7 (14.0%) | 16 (7.4%) | 0.14 | 0.80 |
| Assisted ventilation | 21 (18.1%) | 19 (38.0%) | 40 (18.5%) | 0.003 | 0.006 |
| Deterioration | 39 (33.6%) | 22 (44.0%) | 49 (22.7%) | 0.002 | 0.20 |
| Death from COVID | 20 (17.4%) | 9 (18.4%) | 9 (4.3%) | <0.001 | 0.88 |
| Haemoglobin (g/L), mean (SD) | 132.2 (19.4) | 132.4 (15.3) | 132.3 (20.8) | 0.91 * | 0.95 |
| Neutrophils (×109/L) | 4.3 (2.8, 6.8) | 4.2 (3.3, 7.6) | 4.5 (3.2, 6.4) | 0.29 * | 0.47 |
| Lymphocytes (×109/L) | 0.9 (0.7, 1.3) | 0.9 (0.7, 1.3) | 1.0 (0.7, 1.5) | 0.27 * | 0.60 |
| Neutrophil/Lymphocyte ratio | 4.3 (2.5, 7.5) | 4.4 (3.3, 8.0) | 4.2 (2.6, 7.6) | 0.21 * | 0.36 |
| Platelets (×109/L) | 222.5 (168.5, 275.5) | 199.0 (163.0, 282.0) | 214.0 (157.0, 263.5) | 0.96 * | 0.33 |
| Creatinine (µmol/L), | 77.0 (58.0, 99.0) | 78.0 (60.0, 108.0) | 86.5 (64.0, 115.0) | 0.43 * | 0.53 |
| AST (units/L) | 29.0 (22.0, 44.0) | 42.0 (31.0, 65.0) | 38.0 (27.0, 53.0) | 0.048 * | <0.001 |
| Bilirubin (µmol/L) | 8.0 (5.0, 11.0) | 9.0 (6.0, 12.0) | 9.0 (7.0, 13.5) | 0.60 * | 0.093 |
| Ferritin (ug/L) | 411.5 (181.5, 950.0) | 866.0 (264.0, 1415.0) | 306.0 (130.0, 596.5) | <0.001 * | 0.13 |
| LDH (units/L) | 395.0 (179.0, 919.0) | 320.0 (234.0, 471.0) | 278.0 (215.0, 361.0) | 0.013 * | 0.48 |
| CRP (mg/L) | 47.0 (15.5, 90.0) | 63.5 (11.0, 120.0) | 32.5 (9.0, 88.5) | 0.050 * | 0.29 |
| D-dimer (mg/L FEU) | 0.7 (0.4, 1.4) | 1.3 (0.7, 1.9) | 0.8 (0.5, 1.7) | 0.012 * | <0.001 |
| OCP (units) | 59.8 (44.7, 74.6) | 67.6 (47.9, 80.1) | 56.6 (44.2, 81.1) | 0.20 * | 0.21 |
| OHP (units) | 16.4 (12.1, 24.3) | 23.1 (14.1, 34.9) | 16.5 (10.7, 24.7) | 0.015 * | 0.014 |
| OFP (%) | 70.2 (63.5, 75.7) | 65.1 (54.5, 76.4) | 72.0 (65.4, 77.4) | 0.005 * | 0.083 |
Abbreviations: AST, aspartate transaminase; LDH, lactate dehydrogenase; CRP, C-reactive protein; OCP, overall coagulation potential; OHP, overall hemostatic potential; OFP, overall fibrinolytic potential. * p-values adjusted for sex; boldened values signify p < 0.05.