Table 1.
In vitro susceptibilities of Aspergillus fumigatus to MICAN, DIMICAN, EICAN, PICAN and DIN as determined by CLSI broth microdilution method. Minimum effective concentration (MEC) and 80% inhibitory (MIC80) values are presented. The values in parentheses belong to the molar concentration of the compounds. The best and second-best MIC values are indicated in red and green, respectively.
| Compound | Aspergillus fumigatus Strains | MEC (µg/mL) | MIC80 (µg/mL) |
|---|---|---|---|
| MICAN (182.23 g/mol) a |
A. fumigatus MYA-3627 | 9 (49 µM) | 11 (60 µM) |
| A. fumigatus ATCC 204305 | 9 (49 µM) | 11 (60 µM) | |
| A. fumigatus Af293 | 10 (55 µM) | 12 (66 µM) | |
| DIMICAN (196.25 g/mol) a |
A. fumigatus MYA-3627 | 5 (25 µM) | 7 (36 µM) |
| A. fumigatus ATCC 204305 | 5 (25 µM) | 7 (36 µM) | |
| A. fumigatus Af293 | 6 (30 µM) | 8 (41 µM) | |
| EICAN (196.25 g/mol) a |
A. fumigatus MYA-3627 | 50 (250 µM) | 100 (500 µM) |
| A. fumigatus ATCC 204305 | 50 (250 µM) | 100 (500 µM) | |
| A. fumigatus Af293 | 50 (250 µM) | 100 (500 µM) | |
| PICAN (210.28 g/mol) a |
A. fumigatus MYA-3627 | 50 (240 µM) | 100 (480 µM) |
| A. fumigatus ATCC 204305 | 50 (240 µM) | 100 (480 µM) | |
| A. fumigatus Af293 | 50 (240 µM) | 100 (480 µM) | |
| DIN (178.19 g/mol) a |
A. fumigatus MYA-3627 | 0.3 (1.7 µM) | 0.6 (3.4 µM) |
| A. fumigatus ATCC 204305 | 0.3 (1.7 µM) | 0.6 (3.4 µM) | |
| A. fumigatus Af293 | 0.3 (1.7 µM) | 0.6 (3.4 µM) | |
| AMB (924.08 g/mol) a |
A. fumigatus MYA-3627 | <2 (2.2 µM) | <2 (2.2 µM) |
| A. fumigatus ATCC 204305 | <2 (2.2 µM) | <2 (2.2 µM) | |
| A. fumigatus Af293 | <2 (2.2 µM) | <2 (2.2 µM) |
a Molecular weight (MW) of the compounds.