Table 2.
Similarity between the nonapeptides of SP and GoMYA proteins and predictions of binding with HLA supertypes.
| Protein-UniProt ID | Position | SP nonapeptide | H. sapiens nonapeptide | Localization in SP subunit | Similarity per side chain | Percent identity (Needle) | Agglutination - SP nonapeptide |
Agglutination - H. sapiens nonapeptide |
|---|---|---|---|---|---|---|---|---|
| Attractin-O75882 | 1 | DFCGKGYH | NICGIGWH | S2 | :.||.|:| | 75.0 % | ||
| 2 | FCGKGYHLM | ICGIGWHLV | S2 | .||.|:||: | 77.8 % | |||
| 3 | CGKGYHLM | CGIGWHLV | S2 | ||.|:||: | 87.5 % | |||
| Thymidine phosphorylase-P19971 | 4 | CVLGQSKRV | CIVGQSEQL | S2 | |::|||::: | 100.0 % | ||
| Receptor-type tyrosine-protein phosphatase zeta-P23471 | 5 | SNFRVQPT | NNFSVQPT | S1 | :||.|||| | 87.5 % | ||
| 6 | SNFRVQPTE | NNFSVQPTH | S1 | :||.||||. | 77.8 % | |||
| 7 | NFRVQPTES | NFSVQPTHT | S1 | ||.||||.: | 77.8 % | |||
| Disks large homolog 1-Q12959 | 8 | ESLIDLQEL | QALIDIQEF | S2 | ::|||:||. | 88.9 % | HLA-B*58:01, HLA-A*26:01 | |
| Kinesin-like protein KIF14-Q15058 | 9 | KRISNCVAD | RRISGCLHD | S1 and RBD | :|||.|:.| | 77.8 % | ||
| 10 | PVLKGVKLH | AVLKGSKLH | S2 | .||||.||| | 77.8 % | HLA-A*03:01 | ||
| 11 | VLKGVKLHY | VLKGSKLHF | S2 | ||||.|||: | 88.9 % | HLA-A*03:01, HLA-B*15:01, HLA-A*26:01 | HLA-B*15:01, HLA-B*08:01, HLA-A*24:02 | |
| 12 | LKGVKLHY | LKGSKLHF | S2 | |||.|||: | 87.5 % | |||
| Teneurin-4-Q6N022 | 13 | FGTTLDSK | YGTTLDEE | S1 | :|||||.: | 87.5 % | ||
| Serine/threonine-protein kinase MARK2-Q7KZI7 | 14 | EKSNIIRG | SKSNMIRG | S1 | .|||:||| | 87.5 % | ||
| 15 | TEKSNIIRG | SSKSNMIRG | S1 | :.|||:||| | 88.9 % | |||
| 16 | STECSNLL | STDCENLL | S2 | ||:|.||| | 87.5 % | |||
| Cytoplasmic FMR1-interacting protein 1-Q7L576 | 17 | HRSYLTPGD | NRMYLTPSE | S1 | :|.||||.: | 77.8 % | ||
| 18 | RSYLTPGD | RMYLTPSE | S1 | |.||||.: | 75.0 % | |||
| 19 | EELDKYFKN | SKIDKYFKQ | S2 | .::|||||. | 77.8 % | |||
| 20 | ELDKYFKN | KIDKYFKQ | S2 | ::|||||. | 87.5 % | |||
| Myotubularin-related protein | 21 | YQDVNCTE | YDDVSCTQ | S1 | |.||:||: | 87.5 % | ||
| 13-Q86WG5 | 22 | VLYNSASF | VLFHSASF | S1 and RBD | ||::|||| | 100.0 % | HLA-B*15:01 | HLA-B*15:01 |
| Leucine-rich repeat LGI family member 4-Q8N135 | 23 | TQTNSPRR | TQTLAPRR | S1 | |||.:||| | 87.5 % | ||
| RING finger protein 10- Q8N5U6 |
24 | PAYTNSFTR | PSFQNSFSQ | S1 | |::.|||:: | 88.9 % | ||
| Partitioning defective 3 homolog-Q8TEW0 | 25 | DGYFKIYS | DGHMKVFS | S1 | ||:.|::| | 87.5 % | ||
| 26 | VLPPLLTD | VLPPHLSD | S2 | ||||.|:| | 87.5 % | |||
| 27 | ITDAVDCAL | ISDSADCSL | S1 | |:|:.||:| | 88.9 % | HLA-A*01:01 | HLA-A*01:01 | |
| 28 | DAVDCALDP | DSADCSLSP | S1 | |:.||:|.| | 77.8 % | |||
| Sodium channel protein type 2 subunit alpha-Q99250 | 29 | FGAISSVLN | LGAIPSIMN | S2 | .|||.|::| | 77.8 % | ||
| Junctional adhesion molecule C-Q9BX67 | 30 | GCLIGAEH | GCLIGAVN | S1 | ||||||.: | 87.5 % | ||
| 31 | GCLIGAEHV | GCLIGAVNL | S1 | ||||||.:: | 88.9 % | |||
| Sodium channel protein type 8 subunit alpha-Q9UQD0 | 32 | DLPQGFSAL | DIPQGLVAV | S1 | |:|||..|: | 77.8 % | HLA-B*39:01, HLA-A*26:01, HLA-B*08:01, HLA-B*39:01 | HLA-A*26:01 |
| 33 | PDKVFRSS | PDKVFRSS | S1 | |:|||:|. | 87.5 % | |||
| 34 | EHVNNSYEC | EDVNNKTEC | S1 | |.|||..|| | 66.7 % | |||
| Myelin regulatory factor- Q9Y2G1 |
35 | NDLCFTNV | SDLCFPDI | S1 | :||||.:: | 87.5 % |
SP nonapeptide: Nonredundant nonapeptides in SP that are similar to nonapeptides in H. sapiens GoMYA proteins. H. sapiens nonapeptide: Nonredundant nonapeptides in GoMYA proteins that are similar to nonapeptides in SP. Localization in SP subunit: Localization of the nonapeptide in the SP subunit. Similarity per side chain based on the alignment of nonapeptides in SP and H. sapiens proteins: (:) Similarity by biochemical group,(|) identical residue and (.) different residue. Percent identity (Needle): Identity (expressed as a percentage) obtained from the alignment in Needle. Agglutination - SP and H. sapiens nonapeptides: In silico prediction of the agglutination of nonapeptides in SP or H. sapiens proteins; weak agglutinations are presented in italics.