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. 2022 Oct 27;67(22):2327–2335. doi: 10.1016/j.scib.2022.10.021

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Fig. 2 — Crystal structure of SARS-CoV-2 N-NTD and dsRNA complex. (a) The overall structure of SARS-CoV-2 N-NTD and dsRNA complex (PDB ID: 7XWZ). Each monomer is represented by a different color. (b) Superimposition of SARS-CoV-2 N-NTD between the apo form (wheat) and dsRNA-bound form (green). (c) The electrostatic potential surface of SARS-CoV-2 N-NTD monomer and its bound dsRNA in three orientations. dsRNA is shown as a cartoon representation (Monomer 1: purple; Monomer 2: green; PDB ID: 7ACS, yellow). Blue indicates positive charge potential, while red indicates negative charge potential. (d) Hydrogen bonds between N-NTD monomer 1 and dsRNA. Hydrogen bonds are represented by black dotted lines, and amino acids and nucleotides involved in hydrogen bond interactions are marked. (e) Hydrogen bonds between N-NTD monomer 2 and dsRNA. Hydrogen bonds are represented by black dotted lines, and amino acids and nucleotides involved in hydrogen bond interactions are marked.